0737 Factors Influencing Arousal Thresholds

Abstract Introduction Obstructive Sleep Apnoea (OSA) is the most common sleep-related breathing disorder with an estimated prevalence of approximately 15-30 percent in males and 10-15 females. A low respiratory arousal threshold (ArTH) one several traits involved OSA pathogenesis. This has been shown to be reliably predicted using Arousal Score which calculated patients overall Apnoea-Hypopnoea Index (AHI), nadir SpO2 Hypopnoea:Apnoea ratio where a score 2 or more predicts threshold, 1 indicates high threshold. Our objective was describe factors associated thresholds as determined by metropolitan population. Methods 208 unselected, consecutive, adult, overnight polysomnography prospectively scores were assessed from 2019 – 2020. Demographic anthropometric data including Age, Sex, BMI, Epworth Sleepiness (ESS), AHI, nadir, index recorded. The assigning point for meeting each following requirements: AHI <30; > 82.8%; 58.3, <2 considered low. Spearmann correlation performed determine Score. Results included study. 35.6% had mild sleep apnoea, 23.1% moderate 22.6% severe apnoea 18.8% no apnoea. Mean 2.47 (Std Dev 0.839). Spearman indicated that disease severity, BMI (rs -.374, p-value < 0.01) STOP-BANG (r2 -0.419, statistically significant relationship That is, higher score. Moreover, Gender exhibited insignificant association We found increasing severity lower therefore Conclusion study demonstrates worsening are ESS do not appear significantly associated. Support (If Any)